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Paired Comparison Vasoconstrictor AssaysA Comparison of Methods for the Determination of Relative Vasoconstrictor Potency of Topically Applied Corticosteroids
Boyd J. Poulsen, PhD;
Kenneth Burdick, MD;
Stuart Bessler, PhD
Arch Dermatol. 1974;109(3):367-371.
Abstract
The human vasoconstrictor assay, which is frequently used for potency comparisons of topically applied corticosteroids, relies on the visual measurement of skin blanching produced at the application site. In this report, three different methods of visual measurement were compared. A technique involving paired comparisons of vasoconstriction at adjacent sites was found to improve the assessment of relative vasoconstrictor activity. Corticosteroid creams containing 0.05% fluocinonide, 0.1% betamethasone valerate, and 1% hydrocortisone were evaluated in this study.
Author Affiliations
Palo Alto, Calif
From the Institute of Pharmaceutical Sciences (Dr. Poulsen), the Institute of Clinical Medicine (Dr. Burdick), and the Department of Biostatistics (Dr. Bessler), Syntex Research, Palo Alto, Calif.
Footnotes
Accepted for publication Oct 16, 1973.
Reprint requests to Institute of Pharmaceutical Sciences, Syntex Research, Stanford Industrial Park, Palo Alto, CA 94304 (Dr. Poulsen).
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