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William C. Gentry, Jr., MD; Nyles R. Eskritt, MD; Robert J. Gorlin, DDS

Arch Dermatol. 1974;109(4):521-525.

Abstract
Seven members in three generations of a family have multiple hamartoma syndrome (Cowden disease). Skin changes, characterized by progressive verrucous, papular, and lichenoid lesions involving mucosal and cutaneous surfaces, serve as hallmarks of associated fibrocystic breast disease, carcinoma of the breast, thyroid tumors, gastrointestinal polyposis, nervous system abnormalities, fibromas, angiomas, and lipomas. The syndrome is inherited in an autosomal dominant pattern. It is important to recognize the widespread and diverse mucocutaneous manifestations as signs of possible anatomic, metabolic, and internal abnormalities.

Author Affiliations
Minneapolis

From the Department of Dermatology (Drs. Gentry and Eskritt) and the Division of Oral Pathology (Dr. Gorlin), University of Minnesota Health Sciences Center, Minneapolis. Dr. Eskritt is now with the Rice Clinic, Stevens Point, Wisc.

Footnotes
Accepted for publication Nov 7, 1973.

Read in part before the Section on Dermatology at the 121st annual convention of the American Medical Association, San Francisco, June 19, 1972.

Reprint requests to Department of Dermatology, Box 98 Mayo, University of Minnesota Health Sciences Center, Minneapolis 55455 (Dr. Gentry).

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