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New Immunologic Findings

Lawrence L. Bushkell, MD; Robert E. Jordon, MD; Robert W. Goltz, MD

Arch Dermatol. 1974;110(1):65-69.

Abstract
During the second trimester of pregnancy, a patient developed herpes gestationis characterized by a widespread eruption of iris lesions with peripheral subepidermal vesicles and severe blood eosinophilia. Direct immunofluorescent studies of lesions showed deposition of IgG, C1q, C3, and properdin at the basement membrane, implicating both classic and alternate complement pathway activation. A circulating antibody to basement membrane, previously undescribed, to our knowledge, in this disease, was found, which suggests that herpes gestationis may be related to bullous pemphigoid.

Author Affiliations
Minneapolis; Rochester, Minn; Minneapolis

From the Department of Dermatology, University of Minnesota, Minneapolis (Drs. Bushkell and Goltz) and the Department of Dermatology, the Mayo Clinic, Rochester, Minn (Dr. Jordon).

Footnotes
Accepted for publication Feb 28, 1974.

Reprint requests to Department of Dermatology, Box 98, University of Minnesota Health Sciences Center, Minneapolis, MN 55455 (Dr. Bushkell).

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