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Control of Keratinization With -Hydroxy Acids and Related Compounds

I. Topical Treatment of Ichthyotic Disorders

Eugene J. Van Scott, MD; Ruey J. Yu, PhD

Arch Dermatol. 1974;110(4):586-590.

Abstract
Topical preparations containing -hydroxy acids and closely related compounds were found to exert profound effects on epidermal keratinization in ichthyosis. Therapeutically efficacious compounds include citric acid, ethyl pyruvate, glycolic acid, glucuronic acid, 3-hydroxybutyric acid, 2-hydroxyisobutyric acid, lactic acid, malic acid, methyl pyruvate, pyruvic acid, tartaric acid, and tartronic acid. These materials appear to influence the process of keratinization per se, but do not seem to be keratolytic.

Author Affiliations
From the Skin and Cancer Hospital, Department of Dermatology, Temple University School of Medicine, Philadelphia.

Footnotes
Accepted for publication June 5, 1974.

Reprint requests to Skin and Cancer Hospital, 3322 N Broad St, Philadelphia, PA 19140 (Dr. Van Scott).

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