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Treatment With Topically Applied Tretinoin

John W. Petrozzi, MD; T. Lynn Warthan, MD

Arch Dermatol. 1974;110(5):762-765.

Abstract
Successful treatment of Kyrle disease was achieved with topically applied tretinoin. Its effectiveness appears to depend on its ability to increase epidermal proliferation and to impair keratinization. Because of the beneficial results achieved, a hypothesis that keratinization is excessive in comparison with epidermal proliferation may be valid in the pathogenesis of this disorder.

Author Affiliations
From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia and the Dermatology Section, Veterans Administration Hospital, Philadelphia.

Footnotes
Accepted for publication May 20, 1974.

Reprint requests to Dermatology Section, Veterans Administration Hospital, University and Woodland avenues, Philadelphia, PA 19104 (Dr. Petrozzi).

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