This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Utilization of Immunofluorescence in the Diagnosis of Bullous Diseases, Lupus Erythematosus, and Certain Other Dermatoses

Arch Dermatol. 1975;111(3):371-381.

Abstract
Sera and frozen biopsy specimens taken for immunofluorescence can be of diagnostic value in studies of vesiculobullous eruptions and connective tissue diseases. Appropriate handling of specimens is important. In cases of pemphigus and pemphigoid, findings of typical antibodies in sera and immunoglobulin deposits in skin sections serve to establish the diagnoses. Fluctuations in titers of pemphigus antibodies afford a prognostic guide. IgA deposits at the dermoepidermal junction in patients with vesiculobullous eruptions are diagnostic of dermatitis herpetiformis. Elevated titers of antinuclear antibodies, frequently with a peripheral pattern, and DNA antibodies as well as junctional deposits of immunoglobulins or complement or both in the apparently uninvolved skin are highly characteristic of systemic lupus erythematosus. More or less typical patterns of immunoglobulin and complement deposits in the lesion appear in discoid lupus erythematosus, porphyrias, and some other dermatoses.

Footnotes
Accepted for publication Sept 4, 1974.

This communication is published simultaneously in the International Journal of Dermatology and the Archives, edited and produced in accordance with the style and policies pertinent to the respective journals.

Reprint requests to Department of Microbiology, School of Medicine, State University of New York at Buffalo, 219 Sherman Hall, Buffalo, NY 14214 (Ernst H. Beutner, PhD).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

In Vitro Testing for Allergy: Report II of the Allergy Panel
Council on Scientific Affairs
JAMA 1987;258:1639-1643.
ABSTRACT  

Variability of the Lupus Band Test: Results in 18 Patients With Systemic Lupus Erythematosus
Jacobs et al.
Arch Dermatol 1983;119:883-889.
ABSTRACT  

Anti-Intercellular Substance Antibodies: Presence in Serum Samples of 14 Patients Without Pemphigus
Ahmed and Workman
Arch Dermatol 1983;119:17-21.
ABSTRACT  

Complement-Fixing Intercellular Antibodies in a Case of Cicatricial Pemphigoid
Kumar et al.
Arch Dermatol 1980;116:812-814.
ABSTRACT  

The Correlation of Disease Activity and Antibody Titers in Pemphigus
Fitzpatrick and Newcomer
Arch Dermatol 1980;116:285-290.
ABSTRACT  

Herpetiform Blisters in Systemic Lupus Erythematosus
Penneys and Wiley
Arch Dermatol 1979;115:1427-1428.
ABSTRACT  

Cutaneous Lupus Erythematosus Associated With Melanoma and BCG Vaccine Therapy
Herstoff and Bogaars
Arch Dermatol 1979;115:856-859.
ABSTRACT  

Correlation of Antibodies in Skin and Serum With Disease Severity in Pemphigus
Judd and Lever
Arch Dermatol 1979;115:428-432.
ABSTRACT  

Immunofluorescence of Biopsy Specimens: Comparison of Methods of Transportation
Nisengard et al.
Arch Dermatol 1978;114:1329-1332.
ABSTRACT  

Benign Mucous Membrane Pemphigoid: Response to Therapy With Cyclophosphamide
Brody and Pirozzi
Arch Dermatol 1977;113:1598-1599.
ABSTRACT  

Threads and Fine Threads
Pedro
Arch Dermatol 1976;112:122-122.
ABSTRACT  

Threads and Fine Threads
Burnham
Arch Dermatol 1976;112:122-122.
ABSTRACT