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Subcutaneous Fat Necrosis Associated With Pancreatic Disease
Philip S. H. Hughes, MD;
Prapand Apisarnthanarax, MD;
J. Fred Mullins, MD
Arch Dermatol. 1975;111(4):506-510.
Abstract
Subcutaneous fat necrosis, a type of panniculitis, is a rare entity that is manifested by painless or painful subcutaneous nodules on the legs, buttocks, or trunk and is associated with pancreatitis or carcinoma of the pancreas, either of which may be asymptomatic. The histopathological findings are pathognomonic and consist of subcutaneous focal fat necrosis and "ghost-like" cells with thick, shadowy walls and no nuclei.
Arthritis, particularly of the ankles, is a commonly associated finding. Distant foci of fat necrosis in pancreatic disease are probably due to the local action of hematogenous-borne trypsin and lipase. Since the underlying pancreatic disease may be asymptomatic, histopathologic study of all cases of panniculitis should be considered.
Author Affiliations
From the Department of Dermatology, University of Texas Medical Branch, Galveston.
Footnotes
Accepted for publication Sept 3, 1974.
Reprint requests to Department of Dermatology, University of Texas Medical Branch, Galveston, TX 77550 (Dr. Hughes).
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