This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (28)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Henry H. Roenigk, Jr., MD; Sharad D. Deodhar, MD, PhD; John A. Krebs, MD; Barbara Barna, MS

Arch Dermatol. 1975;111(6):720-725.

Abstract
Microcytotoxicity assays of patients with malignant melanoma and halo nevi were performed. No good correlation could be found between percent cell inhibition and histopathological level of melanoma or the clinical staging. The percent cell inhibition was usually an index of response to vaccinia virus immunotherapy. Actively regressing halo nevi showed high levels of percent cell inhibition, whereas inactive halo nevi had low levels of percent cell inhibition and blocking factor. Immunologic reactivity to melanoma cells may be a common feature of melanoma and halo nevus.

Author Affiliations
From the Department of Dermatology and Immunopathology, the Cleveland Clinic Foundation, Cleveland.

Footnotes
Accepted for publication Dec 19, 1974.

Read before the American Dermatological Association meeting, March 30, 1974, Kona, Hawaii.

Reprint requests to 9500 Euclid Ave, Cleveland, OH 44106 (Dr. Roenigk).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Halo Congenital Nevus Undergoing Spontaneous Regression: Involvement of T-Cell Immunity in Involution and Presence of Circulating Anti--Nevus Cell IgM Antibodies
Tokura et al.
Arch Dermatol 1994;130:1036-1041.
ABSTRACT  

Halo Nevi Without Dermal Infiltrate
Gauthier et al.
Arch Dermatol 1978;114:1718-1718.
ABSTRACT  

Halo Congenital Nevus
Brownstein et al.
Arch Dermatol 1977;113:1572-1575.
ABSTRACT