 |
|
Histocompatibility (HL-A) Antigens in Psoriasis
Leopoldo Krulig, MD;
Eugene M. Farber, MD;
F. Carl Grumet, MD;
Rose O. Payne, PhD
Arch Dermatol. 1975;111(7):857-860.
Abstract
In 101 white psoriatic patients, two histocompatibility (HL-A) specificities were significantly altered from expected values. The levels of W16 and W17 were found to be substantially increased, suggesting that persons with these antigens are at increased risk of having psoriasis. Clinically distinct patient groups were also observed. Antigens W16 or W17 or both were more prevalent in psoriatic patients who had extensive disease involvement, and patients with W17 antigen had an earlier age of onset as compared to patients with W16 antigen. In one family in this study, a linkage between psoriasis and a specific HL-A haplotype was also observed, further supporting the concept that the HL-A system may serve as a marker for genes affecting specific disease susceptibility.
Author Affiliations
From the Department of Dermatology (Drs. Krulig and Farber), Department of Pathology (Dr. Grumet), and Department of Medicine (Dr. Payne), Stanford University Medical Center, Stanford, Calif.
Footnotes
Accepted for publication Oct 1, 1974.
Reprint requests to Department of Dermatology, Stanford University Medical Center, Stanford, CA 94305 (Dr. Farber).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Cyclosporine in Psoriasis Treatment: Inhibition of Keratinocyte Cell-Cycle Progression in G1 Independent of Effects on Transforming Growth Factor {alpha}/Epidermal Growth Factor Receptor Pathways
Khandke et al.
Arch Dermatol 1991;127:1172-1179.
ABSTRACT
The Genetics of Psoriasis: Haplotype Sharing in Siblings With the Disease
Suarez-Almazor and Russell
Arch Dermatol 1990;126:1040-1042.
ABSTRACT
HLA Region Genes and Immune Activation in the Pathogenesis of Psoriasis
Gottlieb and Krueger
Arch Dermatol 1990;126:1083-1086.
ABSTRACT
Mode of Inheritance in Psoriasis
Burch and Rowell
Arch Dermatol 1981;117:251-251.
ABSTRACT
|
