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Kays H. Kaidbey, MD; John W. Petrozzi, MD; Albert M. Kligman, MD

Arch Dermatol. 1975;111(8):1001-1003.

Abstract
The sequential application of tretinoin and a corticosteroid ointment was considerably more effective in the treatment of plaque-type psoriasis than either drug alone in a pilot study.

The best results were obtained with 0.3% tretinoin followed by a potent corticosteroid ointment. Combined therapy was particularly efficacious in steroid-resistant psoriasis, including that on the palms, elbows, and knees.

Irritancy from the high-strength tretinoin was a potentially troublesome sideeffect. Care must be taken to avoid drug contact on areas that are easily irritated.

Author Affiliations
From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, and the Dermatology Section of the Veterans Administration Hospital, Philadelphia.

Footnotes
Accepted for publication Feb 24, 1975.

Reprint requests to Department of Dermatology, Duhring Laboratories, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 (Dr. Kligman).

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