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Aluminum Chloride in the Treatment of Symptomatic Athlete's Foot
James J. Leyden, MD;
Albert M. Kligman, MD, PhD
Arch Dermatol. 1975;111(8):1004-1010.
Abstract
Various aluminum salts were evaluated for in vitro and in vivo antimicrobial activity and ability to bind with serum proteins (astringency) with the object of finding a colorless substance to substitute for carbol-fuchsin solution (Castellani paint) in the treatment of symptomatic interdigital athlete's foot. Aluminum chlorohydrate was more powerful in killing bacteria and fungi than aluminum acetate and aluminum chloride. However, aluminum chloride showed pronounced astringency and was the only compound to bring about rapid resolution of the signs and symptoms of athlete's foot in open-ended clinical trials. This salt promptly controls odor, pruritus, and maceration. The beneficial effect depends largely on drying the surface, not killing organisms. A solution of 30% aluminum chloride was found to be equivalent to carbol-fuchsin solution in effectively treating symptomatic athlete's foot.
Author Affiliations
From the Department of Dermatology, Duhring Laboratories, Hospital of the University of Pennsylvania, Philadelphia.
Footnotes
Accepted for publication Feb 18, 1975.
Reprint requests to Department of Dermatology, Duhring Laboratories, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 (Dr. Leyden).
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