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David Weedon, MB, FRCPA; Leo Barnett, MB, FRACS

Arch Dermatol. 1975;111(8):1024-1026.

Abstract
A keratoacanthoma centrifugum marginatum measured 20x14 cm at the time of surgical intervention. This lesion is characterized by continuing peripheral extension and central healing. Attention is drawn to the occurrence in the healing edge of a distinctive type of individual cell necrosis, which has been described by others in the more usual forms of keratoacanthoma. The findings are of interest, since this same mode of cellular death has recently been shown to be involved in the regression of various tissues, normal as well as abnormal.

Author Affiliations
From the departments of pathology and surgery, Royal Brisbane Hospital, Brisbane, Australia.

Footnotes
Accepted for publication Sept 16, 1974.

Reprint requests to Department of Pathology, Royal Brisbane Hospital, Brisbane, Australia 4029 (Dr. Weedon).

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