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Hendrik M. G. Doeglas, MD; Eric Bleumink, PhD

Arch Dermatol. 1975;111(8):979-985.

Abstract
The hypothesis that deficiencies of plasma protease inhibitors might play a role in the pathogenesis of chronic urticaria was evaluated. Plasma levels were measured in patients with urticaria and a matched control group for ₁-antitrypsin, ₂-macroglobulin, total trypsin-inhibiting capacity, kallikrein-inhibiting capacity, and the complement factors C1 esterase inhibitor, C3, and C4.

A total of 92 patients with chronic urticaria of more than three months' duration was studied. Patients with acquired cold urticaria had significantly decreased levels of ₁-antitrypsin and total antitrypsin activity. In patients with acquired angioneurotic edema, ₁-antitrypsin levels and antichymotrypsin activities were lowered, with less significant decreases in antitrypsin and antikallikrein activities. Levels of C1 esterase inhibitor, C3, and C4 were normal in all groups. There was no correlation between the increased sensitivity to intracutaneously administered kallikrein injection and deficiencies of protease inhibitors.

Author Affiliations
From the Department of Dermatology, State University, Groningen, the Netherlands.

Footnotes
Accepted for publication Feb 4, 1975.

Read in part before the fourth meeting of the European Society for Dermatological Research, Amsterdam, April 24, 1974.

Reprint requests to Department of Dermatology, Oostersingel 59, Groningen, the Netherlands (Dr. Doeglas).

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