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Use of Orally Administered Psoralens and a High-Intensity Long-Wave Ultraviolet Light System

John A. Parrish, MD; Thomas B. Fitzpatrick, MD; Christopher Shea; Madhu A. Pathak, MB, PhD

Arch Dermatol. 1976;112(11):1531-1534.

Abstract
• A new light source that provides highintensity ultraviolet light (UVA) (300 to 400 nm) to the entire body surface makes orally administered psoralen treatment of vitiligo with an artificial light practical. In the 26 patients studied, the degree of repigmentation with either trioxsalen (TMP) or methoxsalen (8-MOP) and high intensity UVA was at least as great as that with the same oral agents and sunlight. With artificial UVA and similar treatment conditions, the two psoralen derivatives were compared in the treatment of vitiligo; TMP stimulated repigmentation as well as 8-MOP and caused fewer side effects.

(Arch Dermatol 112:1531-1534, 1976)

Author Affiliations
From the Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston.

Footnotes
Accepted for publication Jan 7, 1976.

Reprint requests to Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114 (Dr Parrish).

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