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A Clinicopathologic Study

Kenneth C. Hertz, MD; Stephen I. Katz, MD, PhD; John Maize, MD; A. Bernard Ackerman, MD

Arch Dermatol. 1976;112(11):1543-1548.

Abstract
• Herpes gestationis is a pruritic, blistering eruption of pregnancy and the puerperium. In three patients with immunologically verified disease, the clinical presentation consisted of widespread erythematous, edematous papules and plaques, grouped vesicles on erythematous bases, and tense bullae. Histologically, these lesions showed a moderately dense, mixed-inflammatory cell infiltrate around superficial and deep dermal blood vessels, and focal necrosis of epidermal basal cells. Papillary dermal edema, subepidermal bullae, and spongiosis were prominent. Eosinophils were frequently present in the subepidermal and intraepidermal vesicles. Differentiation of herpes gestationis from other blistering diseases and other dermatitides of pregnancy may be difficult.

(Arch Dermatol 112:1543-1548, 1976)

Author Affiliations
From the Dermatology Branch, National Cancer Institute, Bethesda, Md (Drs Hertz and Katz), and the Dermatopathology Section, Skin and Cancer Unit, New York University Medical Center, New York (Drs Maize and Ackerman).

Footnotes
Accepted for publication March 10, 1976.

Reprint requests to Building 10, Room 12N238, National Cancer Institute, National Institutes of Health, Bethesda, MD 20014 (Dr Hertz).

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