This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (35)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Neal S. Penneys, MD, PhD; Vincent Ziboh, PhD; Paul Simon, MD

Arch Dermatol. 1976;112(7):955-957.

Abstract
• As a result of ultraviolet light and coal tar therapy, a white ring (Woronoff) may develop in the normal skin adjacent to psoriatic plaques. Injection of prostaglandin E₂ (PGE₂) 1 cm outside of Woronoff ring produced redness in the ring, demonstrating that vessels within the ring were not unresponsive to PGE₂. Whole skin homogenates from Woronoff ring contained an inhibitor of prostaglandin synthesis that was not found in uninvolved skin that was obtained from either psoriatics or normal controls. Prostaglandin E₂ levels in the ring were one third of those in uninvolved skin from either psoriatics or normal controls. These findings suggest that the white ring that surrounds ultraviolet-light-treated psoriatic plaques is produced by a local inability to synthesize PGE₂ in response to an ultraviolet light stimulus, resulting from the presence of an inhibitor of prostaglandin synthesis.

(Arch Dermatol 112:955-957, 1976)

Author Affiliations
Jon Lord

From the departments of dermatology (Drs Penneys, Ziboh, and Simon) and biochemistry (Dr Ziboh), University of Miami School of Medicine, Miami.

Footnotes
Accepted for publication June 4, 1975.

Reprint requests to the Department of Dermatology, University of Miami School of Medicine, Box 520875, Miami, FL 33152 (Dr Penneys).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Implications of Dietary Oils and Polyunsaturated Fatty Acids in the Management of Cutaneous Disorders
Ziboh
Arch Dermatol 1989;125:241-245.
ABSTRACT  

Action of Topically Applied Arachidonic Acid on the Skin of Patients With Psoriasis
Hebborn et al.
Arch Dermatol 1988;124:387-391.
ABSTRACT  

Woronoff Ring During Anthralin Therapy for Psoriasis
Gupta et al.
Arch Dermatol 1986;122:248-248.
ABSTRACT  

Woronoff's Rings With PUVA Therapy
Warin and Greaves
Arch Dermatol 1979;115:105-105.
ABSTRACT  

Woronoff's Ring in Goeckerman Treatment of Psoriasis
Rogers
Arch Dermatol 1978;114:963-963.
ABSTRACT  

Woronoff's Rings With PUVA Therapy
Lowe and Bures
Arch Dermatol 1978;114:278-279.
ABSTRACT  

Pathogenesis of Erythromelalgia
Jorgensen and Sondergaard
Arch Dermatol 1978;114:112-114.
ABSTRACT