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T and B Lymphocytes in Contact and Atopic Dermatitis
Francisco J. Carapeto, MD;
Richard K. Winkelmann, MD, PhD;
Robert E. Jordon, MD
Arch Dermatol. 1976;112(8):1095-1100.
Abstract
• The pattern of distribution of T and B lymphocytes was investigated in a group of patients with contact, atopic, and mixed dermatitis by means of immunofluorescence and T-cell rosette tests. A significant increase (P < .001 ) in B lymphocytes with surface IgD but without changes in the lymphocytes bearing other immunoglobulins or C3 and T cells was noted in patients with contact dermatitis when compared with a control group. A significant increase (P < .001) in B lymphocytes carrying IgE and a significant decrease (P < .001) in the total numbers of T cells were noted in patients with atopic dermatitis, and a significant increase in B lymphocytes positive for IgD (P < .001) and IgE (P < .003) with a decrease in the number of lymphocytes bearing IgG were the most important changes observed in patients with mixed contact and atopic dermatitis.
(Arch Dermatol 112:1095-1100, 1976)
Author Affiliations
From the Cutaneous Immunopathology Unit (Dr Jordon) and the departments of dermatology (Drs Carapeto, Winkelmann, and Jordon) and immunology (Dr Jordon), Mayo Clinic and Mayo Foundation, Rochester, Minn.
Footnotes
Accepted for publication Nov 4, 1975.
Read in part before the joint meeting of the Society for Investigative Dermatology and the European Society for Dermatologic Research, Amsterdam, June 13, 1975.
Reprint requests to Mayo Clinic, Rochester, MN 55901 (Dr Jordon).
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