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Thomas Breza, MD; J. Richard Taylor, MD; William H. Eaglstein, MD

Arch Dermatol. 1976;112(9):1256-1258.

Abstract
• Sequential topical application of fluorouracil and 0.5% triamcinolone acetonide cream is as effective in the treatment of actinic keratoses as fluorouracil alone, but the combination obviates the unpleasent irritation caused by fluorouracil. Diluted (0.1%) triamcinolone acetonide cream preparations are ineffective in the suppression of the associated inflammation. There is no detectable difference in the number of new actinic keratoses between the combination therapy and fluorouracil alone.

These findings demonstrate that the degree of success with fluorouracil therapy in actinic keratosis is not related to the degree of inflammation associated with the treatment and are consistent with a chemotherapeutic explanation of fluorouracil's effect on actinic keratosis.

(Arch Dermatol 112:1256-1258, 1976)

Author Affiliations
From the Dermatology Service, Veterans Administration Hospital, and the Department of Dermatology, University of Miami School of Medicine, Fla.

Footnotes
Accepted for publication Nov 13, 1975.

Reprint requests to Division of Dermatology, Veterans Administration Hospital, 1201 NW 16th St, Miami, FL 33152 (Dr Taylor).

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