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Immunofluorescence Findings

Stuart Sobel, MD; Robert Miller, MD; Harry Shatin, MD

Arch Dermatol. 1976;112(9):1280-1283.

Abstract
• A 56-year-old woman developed a vesicular and bullous eruption followed by an efflorescence of lichenoid papules. The clinical and histologic features of this case were consistent with a diagnosis of lichen planus pemphigoides. Direct and indirect immunofluorescence studies demonstrated both in vivo-bound and circulating IgG with specificity for the epidermal basement membrane zone. A common pathogenic immunologic mechanism may exist for both lichen planus and lichen planus pemphigoides, which we believe are clinical variants of a similar disease process.

(Arch Dermatol 112:1280-1283, 1976)

Author Affiliations
From the Department of Dermatology, Mount Sinai School of Medicine of the City University of New York.

Footnotes
Accepted for publication July 7, 1975.

Read before the Section on Dermatology, New York Academy of Medicine, New York, May 7, 1975.

Reprint requests to 4400 Sheridan St, Hollywood, FL 33021 (Dr Sobel).

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