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Report of Two Cases

James P. H. Byrne, MA, MB, MRCP (I), MRCP (UK); Mark Hewitt, MD, FRCP; Roy Summerly, MB, FRCP, FRCP (Edin)

Arch Dermatol. 1976;112(9):1297-1301.

Abstract
• In two patients, active chronic hepatitis was complicated by the development of pyoderma gangrenosum. The favorable response of the pyodermatous lesions to azathioprine therapy suggests that this drug may be of value in treating this disorder in patients for whom corticosteroid therapy produces no benefit or is contraindicated because of side effects. Azathioprine, too, is a potentially toxic drug and may need to be discontinued. Possible causal relationships between pyoderma gangrenosum and active chronic hepatitis are discussed.

(Arch Dermatol 112:1297-1301, 1976)

Author Affiliations
From the North Staffordshire Hospital Centre, Stoke-on-Trent, England (Drs Byrne and Summerly), and the Cornwall and Isles of Scilly Area Health Authority (Dr Hewitt).

Footnotes
Accepted for publication Oct 15, 1975.

Reprints not available.

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