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Gerd Michaëlsson, MD; Lennart Juhlin, MD; Anders Vahlquist, MD

Arch Dermatol. 1977;113(1):31-36.

Abstract
• The effects of oral zinc sulfate (corresponding to 135 mg of zinc daily) alone and in combination with vitamin A (300,000 international units) daily on acne lesions have been compared with those of vitamin A alone and of a placebo. The number of comedones, papules, pustules, and infiltrates were counted at each visit. After four weeks, there was a significant decrease in the number of papules, pustules, and infiltrates in the zinc-treated groups. The effect of zinc plus vitamin A was not better than zinc alone. After 12 weeks of treatment, the mean acne score had decreased from 100% to 15%. The mechanism for the effect of zinc therapy in acne, to our knowledge, is not presently known.

(Arch Dermatol 113-31-36, 1977)

Author Affiliations
From the Department of Dermatology (Drs Michaëlsson, Juhlin, and Vahlquist) and Clinical Research II (Dr Vahlquist), Uppsala University Hospital, Uppsala, Sweden.

Footnotes
Accepted for publication Nov 13, 1975.

Reprint requests to Department of Dermatology, University Hospital/S-750 14, Uppsala 14, Sweden (Dr Michaëlsson).

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