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Jeffrey P. Callen, MD; Howard V. Dubin, MD; Charles F. Gehrke, MD

Arch Dermatol. 1977;113(11):1585-1586.

Abstract
• Pyoderma gangrenosum has been associated with myelogenous leukemia and plasma cell dyscrasia. When associated with leukemia, pyoderma gangrenosum often has a distinctive clinical presentation with an advancing bullous margin. The pathogenesis of this disorder is unknown, although defective immune mechanisms may be operative. The occurrence of pyoderma gangrenosum and agnogenic myeloid metaplasia in the same patient has now been reported sufficiently to make it a recognized association.

(Arch Dermatol 113:1585-1586, 1977)

Author Affiliations
From the Departments of Dermatology (Drs Callen and Dubin) and Internal Medicine (Simpson Memorial Institute) (Dr Gehrke), University of Michigan Medical School, Ann Arbor.

Footnotes
Accepted for publication Sept 27, 1976.

Reprint requests to Department of Dermatology, University of Louisville School of Medicine, Louisville, KY 40202 (Dr Callen).

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