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Raul Fleischmajer, MD; Jerome S. Perlish, PhD; William P. West, MS

Arch Dermatol. 1977;113(12):1661-1666.

Abstract
• Electron microscopy of the skin was performed in ten patients with systemic and four with localized scleroderma. The following three groups of cells were identified: (1) mature lymphocytes, T lymphoblasts, immature plasma cells, and plasma cells; (2) fibroblasts, fibrocytes, and fibroblast-like cells; and (3) macrophages, undifferentiated mesenchymal cells, and monocytes. In those specimens with mononuclear cell infiltrates, the most common cells were lymphocytic-types, macrophages, and fibroblasts with well developed rough endoplasmic reticulum. In the specimens at the fibrotic stage, fibroblasts and histiocytic-type cells predominated. This study suggests that cellular and humoral immunity may play a role in the pathophysiology of scleroderma.

(Arch Dermatol 113:1661-1666, 1977)

Author Affiliations
From the Division of Dermatology, Department of Medicine, Hahnemann Medical College and Hospital, Philadelphia.

Footnotes
Accepted for publication June 13, 1977.

Reprint requests to Hahnemann Medical College, 245 N 15th St, Philadelphia, PA 19102 (Dr Fleischmajer).

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