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Pemphigus-like Antibodies in Bullous Pemphigoid
Karl G. Heine, MD;
Adarsh Kumar, MD;
Robert E. Jordon, MD
Arch Dermatol. 1977;113(12):1693-1695.
Abstract
• A patient had clinical, histopathologic, and direct immunofluorescent findings compatible with a diagnosis of bullous pemphigoid. In addition, the patient's serum contained pemphigus-like antibodies with different antigenic specificities than true pemphigus antibodies. Absorption of the patient's serum with AB substance failed to block the intercellular substance staining but allowed the demonstration of a basement membrane zone reactive antibody as well. Atypical cases such as this should not cast doubt on the usefulness of immunofluorescence in the diagnosis of bullous skin diseases.
(Arch Dermatol 113:1693-1695, 1977)
Author Affiliations
From the Cutaneous Immunopathology Unit (Drs Heine and Jordon) and the Department of Dermatology (Dr Jordon), Mayo Medical School and Foundation, Rochester, Minn; and the Springfield (Ill) Clinic (Dr Kumar).
Footnotes
Accepted for publication Oct 5, 1976.
Reprint requests to Section of Dermatology, Medical College of Wisconsin, Milwaukee, WI 53226 (Dr Jordon).
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