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Gastrointestinal Absorption of Griseofulvin From Corn Oil-in-Water EmulsionsEffect of Amount of Corn Oil Ingested in Man
Theodore R. Bates, PhD;
Henry J. Pieniaszek, Jr;
Joel A. L. Sequeira;
James E. Rasmussen, MD
Arch Dermatol. 1977;113(3):302-306.
Abstract
• The effect of the amount of emulsified corn oil ingested on the gastrointestinal absorption of griseofulvin in man was assessed after oral administration of 5, 10,15, or 30 gm doses of a corn oil (40% w/w)-in-water emulsion dosage form, each containing 250 mg of microsize griseofulvin. For comparison, griseofulvin absorption from two-125 mg commercial tablets of ultramicrosize drug dispersed in polyethylene glycol 6,000 was also determined. Griseofulvin was almost completely absorbed from the microsize drug emulsions and ultramicrosize drug tablets, whereas 50% of an oral dose is absorbed from commercial microsize griseofulvin tablets. Only 4 gm of emulsified corn oil (as a 10-gm dose of emulsion) is required to maximize the uniformity and extent of griseofulvin absorption. The emulsion dosage form is uniquely suited for pediatric use.
(Arch Dermatol 113:302-306, 1977)
Author Affiliations
From the Department of Pharmaceutics, School of Pharmacy (Dr Bates and Mr Pieniaszek and Sequeira), and the Department of Dermatology, School of Medicine (Dr Rasmussen), State University of New York at Buffalo.
Footnotes
Accepted for publication June 21, 1976.
Reprint requests to Department of Pharmaceutics, State University of New York at Buffalo, Buffalo, NY 14214 (Dr Bates).
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