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Use in the Treatment of Psoriasis and Eczema

Dowling D. Munro, MD, FRCP; Trevor W. E. Robinson, MB, FRCP; Anthony W. P. du Vivier, MRCP; Dorothy M. France, MB, MRCP; Roger Clayton, MB, MRCP; Christopher G. Sparkes, PhD

Arch Dermatol. 1977;113(5):599-601.

Abstract
• Betamethasone 0.1% as valerate in an ointment base and fluocinonide 0.05% in a fatty alcohol propylene glycol (FAPG) base have been compared in a double-blind trial of 76 patients with either eczema or psoriasis. The results show betamethasone valerate ointment to be significantly (P < .05) superior to fluocinonide FAPG in the treatment of both these skin conditions. In the light of publications from other studies on betamethasone valerate cream this trial indicates that the ointment base considerably increases the efficacy of betamethasone valerate.

(Arch Dermatol 113:599-601, 1977)

Author Affiliations
From St Bartholomew's Hospital (Dr Munro); University College Hospital (Drs Robinson and France); St Mary's Hospital (Drs du Vivier and Clayton), London; and the Clinical Research Unit, Glaxo Laboratories Ltd, Greenford, England (Dr Sparkes). Dr France is now with the Crawley Hospital, Crawley, Sussex, England.

Footnotes
Accepted for publication April 21, 1976.

Reprint requests to Medical Department, Glaxo Laboratories Ltd, Greenford, Middlesex, England (Dr Sparkes).

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