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Joseph F. Walter, MD; Peter R. DeQuoy

Arch Dermatol. 1978;114(10):1463-1465.

Abstract
• Anthracene plus near ultraviolet (UV) light (UV-A, 320 to 400 nm) suppresses DNA synthesis and mitosis in mouse epidermis. Ultraviolet-A light or anthracene alone does not have any effect. There is no photoactivation of anthracene to enhance depression of DNA synthesis by either UV-B (290 to 320 nm) or UV-C (254 nm) light. While methoxsalen with UV-A light inhibits DNA synthesis, the phototoxic drugs chlorpromazine hydrochloride and demethylchlortetracycline do not. The combination of anthracene plus UV-A light may have therapeutic effectiveness for psoriasis with less potential for photocarcinogenesis than psoralens plus UV-A light.

(Arch Dermatol 114:1463-1465, 1978)

Author Affiliations
From the Division of Dermatology, University of California, San Diego, School of Medicine.

Footnotes
Accepted for publication June 2, 1978.

Reprint requests to Division of Dermatology, University Hospital, 225 W Dickinson St, San Diego, CA 92103 (Dr Walter).

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