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Therapy in Patients With and Without Diabetes Mellitus

Thomas F. Downham II, MD; Thomas A. Chapel, MD

Arch Dermatol. 1978;114(11):1639-1642.

Abstract
• Retrospective analysis of 34 patients with bullous pemphigoid (BP) showed 24 (70.6%) with widespread disease and 10 (29.4%) with localized disease. Initial prednisone therapy was significantly lower for patients with localized BP, mean dose of 38 mg vs 58 mg, compared with widespread disease. Fifteen of 24 (62%) patients responded; however, 9 (38%) failed to respond to moderate-dose prednisone therapy and ultimately required daily doses of 100 mg or more and/or an immunosuppressive agent. Adult-onset diabetes mellitus was present in 14 of 34 (41%) patients. Initial prednisone dose for diabetic patients with widespread BP was significantly greater, 70 mg vs 54 mg, compared with nondiabetic patients. Addition of methotrexate, 2.5 to 15 mg, every other day or twice-weekly oral administration, was effective when moderate-dose prednisone therapy failed. It is possible that insulin-dependent diabetic patients with BP should be preferentially started on immunosuppressive drugs.

(Arch Dermatol 114:1639-1642, 1978)

Author Affiliations
From the Department of Dermatology, Harper and Detroit General Hospitals, Detroit Medical Center, and Wayne State University School of Medicine.

Footnotes
Accepted for publication July 26, 1978.

Reprint requests to Department of Dermatology and Syphilology, Wayne State University School of Medicine, Scott Hall, 540 E Canfield Ave, Detroit, MI 48202 (Dr Downham).

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