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Hasina Thawerani, MD; Ramón L. Sanchez, MD; Juan Rosai, MD; Ronald F. Dorfman, MRCPath

Arch Dermatol. 1978;114(2):191-197.

Abstract
• Ten patients with sinus histiocytosis with massive lymphadenopathy (SHML) also had cutaneous involvement. Seven of the ten were children. The skin lesions were solitary in three patients and multiple in seven. They were papular or nodular, up to 4 cm in diameter, and often had a xanthomatous appearance. Microscopically, they were constituted by a dermal infiltrate made up predominantly of histiocytes, plasma cells, and lymphocytes. Some of the histiocytes contained phagocytosed lymphocytes in their cytoplasm. The microscopic differential diagnosis includes dermatofibroma, xanthoma, Tangier disease, histiocytosis X, reticulohistiocytoma, juvenile xanthogranuloma, and leprosy.

(Arch Dermatol 114:191-197, 1978)

Author Affiliations
From the Departments of Laboratory Medicine-Pathology and Dermatology, University of Minnesota Medical School, Minneapolis; and the Department of Pathology, Stanford (Calif) University Medical School.

Footnotes
Accepted for publication April 15, 1977.

Reprint requests to Box 609, Mayo Building, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455 (Dr Rosai).

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