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A Family Study

Garry B. Gewirtzman, MD; Norman W. Winkler, MD, PhD; Richard L. Dobson, MD

Arch Dermatol. 1978;114(2):259-261.

Abstract
• Erythrokeratodermia variabilis is a rare genodermatosis; American authors have reported only four previous cases. It had been a problem to obtain a large pedigree for clinical investigation. We studied a family with 12 involved members in five generations.

Symmetrically distributed migratory patches and scaling plaques are characteristic and were found to involute with a combination of keratolytic agents and topical steroids. Exacerbations of these patches and plaques were noted in our female patients during such high estrogen states as pregnancy or oral contraceptive usage.

(Arch Dermatol 114:259-261, 1978)

Author Affiliations
From the Department of Dermatology, State University of New York at Buffalo. Dr Gewirtzman is now in private practice in Plantation, Fla.

Footnotes
Accepted for publication March 23, 1977.

Reprints not available.

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