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John A. Kazmierowski, MD; Michael J. Chusid, MD; Joseph E. Parrillo, MD; Anthony S. Fauci, MD; Sheldon M. Wolff, MD

Arch Dermatol. 1978;114(4):531-535.

Abstract
• We report the histopathologic and dermatologic manifestations of eight patients with hypereosinophilic syndrome (HES). Skin lesions occurred in eight patients (53%) in a group of 15 patients with HES, and were generally of two types: (1) erythematous pruritic papules and nodules, or (2) urticaria and angioedema. As HES was treated with appropriate therapy, the skin lesions improved. Skin eruption may be the only manifestation of disease in otherwise asymptomatic patients with HES.

(Arch Dermatol 114:531-535, 1978)

Author Affiliations
From the Laboratory of Clinical Investigation, the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Dr Kazmierowski is now with the Department of Dermatology, University of Oregon Health Sciences Center, Portland. Dr Chusid is now with the Department of Pediatrics, the Medical College of Wisconsin, Milwaukee.

Footnotes
Accepted for publication June 20, 1977.

Reprint requests to Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20014 (Dr Fauci).

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