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Neutrophil Chemotaxis in Patients With Atopic Dermatitis Without Infection
Mark V. Dahl, MD;
K. Lynn Cates, MD;
Paul G. Quie, MD
Arch Dermatol. 1978;114(4):544-546.
Abstract
Atopic dermatitis has been associated with recurrent infection and impaired neutrophil chemotaxis in some patients. In order to determine if dermatitis per se could decrease polymorphonuclear leukocyte (PMN) chemotaxis, we investigated chemotaxis in 13 patients with atopic dermatitis and no clinical or historical evidence of recurrent or severe infections. Most patients had extensive, but mild, disease. Leukocyte chemotaxis was measured by the Boyden chamber and agarose techniques. There was no difference between patient and control neutrophil chemotactic activity. These findings suggest that atopic dermatitis is not ordinarily associated with impaired PMN chemotaxis in the absence of generalized erythroderma or increased susceptibility to infection.
(Arch Dermatol 114:544-546, 1978)
Author Affiliations
From the Departments of Dermatology and Pediatrics, University of Minnesota Medical School, Minneapolis.
Footnotes
Accepted for publication Nov 18, 1977.
Reprint requests to Department of Dermatology, Box 98 University Hospitals, 420 Delaware St SE, Minneapolis, MN 55455 (Dr Dahl).
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ABSTRACT
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