This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Correlation of Clinical Features and Laboratory Findings in 46 Patients With a Subset of Connective Tissue Disease Characterized by Antibody to Extractable Nuclear Antigen

Stephen D. Prystowsky, MD; Denny L. Tuffanelli, MD

Arch Dermatol. 1978;114(5):705-710.

Abstract
• Clinical and laboratory findings were correlated from 46 patients with IgG localization in epidermal nuclei in a speckled (particulate) pattern on direct immunofluorescence of normal skin. Cutaneous manifestations included lupus erythematosus (LE), swollen hands or sclerodactyly, alopecia, vasculitis, and dyspigmentation. Systemic manifestations included arthritis or arthralgia, Raynaud's phenomenon, serositis, vascular headaches, mild renal disease, myositis, and sicca syndrome.

High titer (mean = 1:142, 800) serum antibody to extractable nuclear antigen (ENA) was found in 81%. Eighty-six percent had antibody to an RNase-sensitive antigenic component of ENA (ribonucleoprotein or RNP); 14% had antibody to an RNase-resistant ENA termed Sm.

Deposition of IgG in a speckled pattern in epidermal nuclei is an immunopathologic marker for a subset of connective tissue disease characterized by antibody to ENA. Those with Sm specificity had systemic LE (SLE). Those with RNP specificity had Raynaud's phenomenon usually associated with overlapping features of SLE, scleroderma, and/or dermatomyositis.

(Arch Dermatol 114:705-710, 1978)

Author Affiliations
From the Department of Dermatology, University of California Medical School, San Francisco.

Footnotes
Accepted for publication Sept 9, 1977.

Reprint requests to Department of Dermatology, University of California Medical School, San Francisco, CA 94143 (Dr Prystowsky).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Antibodies Inside Our Keratinocytes?
Sontheimer
Arch Dermatol 1993;129:1184-1187.
ABSTRACT  

Pemphigus Vulgaris With a High Titer of Antinuclear Antibodies
Grunwald et al.
Arch Dermatol 1984;120:996-996.
ABSTRACT