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Effects With and Without Hydrocortisone

Louis B. Fisher, PhD; Howard I. Maibach, MD; Ronald J. Trancik, PhD

Arch Dermatol. 1978;114(5):727-729.

Abstract
• This study elaborates on the effect of occlusive, partially occlusive, and nonocclusive tape systems containing hydrocortisone on human epidermal mitotic activity that has been increased by tape stripping. The experimental variables included tape delivery systems affording total, partial (50%), or no occlusion to normal human skin. The test corticosteroid was hydrocortisone at a dose range of 1, 4, and 20 µg/sq cm. Utilizing demecolcine cream, biopsy specimens, were taken and mitotic figures determined. Results suggest that potent antimitotic effects occur equally with semiocclusive and nonocclusive tapes containing hydrocortisone as with total occlusive tapes. Verification of the practicality of this in clinical use will depend on appropriate clinical trials in diseased states.

(Arch Dermatol 114:727-729, 1978)

Author Affiliations
From the Division of Dermatology, Scripps Clinic and Research Foundation, La Jolla, Calif (Dr Fisher); the Department of Dermatology, University of California, San Francisco Medical Center (Dr Maibach); and Dermatologicals Project, Riker Laboratories, Inc, 3M Co, St Paul (Dr Trancik).

Footnotes
Accepted for publication Dec 16, 1977.

Reprint requests to Department of Dermatology, University of California, San Francisco Medical Center, San Francisco, CA 94143 (Dr Maibach).

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