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Dowling Degos Disease, A New Genodermatosis

Edward Wilson Jones, FRCP, MRCPath; Katherine Grice, MD

Arch Dermatol. 1978;114(8):1150-1157.

Abstract
• Acquired reticulate pigmentation of the flexures developed in ten patients. Additional features in some cases were pitted scars near the angles of the mouth and scattered dark comedone-like lesions on the neck (dark dot follicles). The disease affects both sexes, usually develops in early adult life, and is slowly progressive. The abnormality is characterized by pigmented filiform epidermal downgrowths closely resembling an adenoid seborrheic wart, but similar proliferations also develop around the variably dilated pilosebaceous follicles. The occurrence of the anomaly in siblings and in mother and daughter in two families suggests the condition in a new genodermatosis. Reticulate pigmented anomaly of the flexures bears a spurious clinical resemblance to acanthosis nigricans and, thus, the recognition of this new genodermatosis should spare patients undergoing unnecessary investigations to exclude visceral malignancy.

(Arch Dermatol 114:1150-1157, 1978)

Author Affiliations
From the Institute of Dermatology, London, and the Department of Dermatology, Watford and Hemel Hempstead General Hospitals, England.

Footnotes
Accepted for publication March 31, 1978.

Reprint requests to St John's Hospital for Diseases of the Skin, Lisle St, London, WC2H 7BJ, Great Britain (Prof Wilson Jones).

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