This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (31)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

John L. Millns, MD; Frederic C. McDuffie, MD; Sigfrid A. Muller, MD; Robert E. Jordon, MD

Arch Dermatol. 1978;114(8):1177-1181.

Abstract
• An unusual case of photosensitive psoriasis and systemic lupus erythematosus-related syndrome was characterized by erythroderma, chronic urticaria, angioneurotic edema, intermittent lowgrade fever, and polyarthralgias. Investigation revealed no measurable total hemolytic complement and markedly diminished levels of C4, C2, and C3. Microscopic examination of three skin biopsy sections of sun-exposed skin showed psoriasis. Skin biopsy sections of sunexposed psoriatic plaques and of non-sun-exposed, uninvolved skin (which were stained with fluorescein-tagged anti-IgG, anti-IgM, anti-IgA, and anti-C3) showed granular deposits of IgM and C3 at the dermal-epidermal junction in the sun-exposed plaques, and IgM alone in a granular pattern at the dermal-epidermal junction in uninvolved skin. Antibodies to single-stranded but not double-stranded DNA were detected in the patient's serum. In addition, serum immune complex-like material was detected by sucrose densitygradient ultracentrifugation, standard anticomplementary assays, and radioimmunoassays using both C1q and monoclonal rheumatoid factor.

(Arch Dermatol 114:1177-1181, 1978)

Author Affiliations
From the Departments of Dermatology (Drs Millns and Muller) and Rheumatology (Dr McDuffie), Mayo Medical School, Mayo Clinic and Foundation, Rochester, Minn, and the Division of Dermatology, Medical College of Wisconsin, Milwaukee County General Hospital (Dr Jordon).

Footnotes
Accepted for publication Feb 3, 1978.

Reprint requests to Section of Publications, Mayo Clinic, 200 First St SW, Rochester, MN 55901 (Dr Millns).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Long-term Risks of Psoralen and UV-A Therapy for Psoriasis
Farber et al.
Arch Dermatol 1983;119:426-431.
ABSTRACT  

Antinuclear Antibodies and PUVA Photochemotherapy
Kubba et al.
Arch Dermatol 1981;117:474-477.
ABSTRACT  

The Coexistence of Psoriasis and Lupus Erythematosus: An Analysis of 27 Cases
Millns and Muller
Arch Dermatol 1980;116:658-663.
ABSTRACT  

Photochemotherapy and Psoriatic Arthritis: A Prospective Study
PERLMAN et al.
ANN INTERN MED 1979;91:717-722.
ABSTRACT  

Antinuclear Antibodies and Oral Methoxsalen Photochemotherapy (PUVA) for Psoriasis
Stern et al.
Arch Dermatol 1979;115:1320-1324.
ABSTRACT  

Systemic Lupus Erythematosus: Association With Psoralen-Ultraviolet-A Treatment of Psoriasis
Eyanson et al.
Arch Dermatol 1979;115:54-56.
ABSTRACT