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Evidence for Both Neutrophil and Lymphocyte Dysfunction

R. Thomas Jessen, MD; Dennis E. Van Epps, PhD; James S. Goodwin, MD; James Bowerman, MD

Arch Dermatol. 1978;114(8):1182-1186.

Abstract
• A child with incontinentia pigmenti (Bloch-Sultzberger syndrome) had recurrent pneumococcal meningitis and pneumococcal bacteremia with associated subdural hematomas. Immunologic evaluation revealed defective neutrophil chemotaxis with normal neutrophil chemiluminescense. In addition, lymphocytes showed a depressed proliferative response to phytohemagglutinin stimulation. An immunologic defect may prove to be part of this syndrome.

(Arch Dermatol 114:1182-1186, 1978)

Author Affiliations
From the Veteran's Administration Hospital and Division of Dermatology (Dr Jessen), Department of Medicine (Drs Jessen, Van Epps, and Goodwin), Department of Microbiology (Dr Van Epps), and the Department of Pediatrics (Dr Bowerman), University of New Mexico School of Medicine, Albuquerque.

Footnotes
Accepted for publication Feb 3, 1978.

Reprint requests to Division of Dermatology, University of New Mexico School of Medicine, 2701 Frontier, NE, Albuquerque, NM 87131 (Dr Jessen).

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