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Complement-Fixing Pemphigus Antibodies
Takashi Hashimoto, MD;
Takeji Nishikawa, MD;
Seiichi Kurihara, MD;
Hitoshi Hatano, MD
Arch Dermatol. 1978;114(8):1191-1192.
Abstract
• The serum of a patient with a typical case of pemphigus vulgaris contained complement-fixing intercellular autoantibodies (pemphigus antibodies). Complement-fixing pemphigus antibodies were demonstrated only during the untreated active stage of the disease and titrated lower than corresponding IgG autoantibodies, which paralleled well with the disease activity. Pemphigus lesional skin, which contained in-vivo-bound IgG, showed the capability of further binding C3 in vitro from normal human serum. It was suggested from these findings that the complement system may play an active role in pemphigus acantholysis through complement-fixing pemphigus antibodies.
(Arch Dermatol 114:1191-1192, 1978)
Author Affiliations
From the Department of Dermatology, Keio University School of Medicine, Tokyo. Dr Hashimoto is now with the Tachikawa Kyosai Hospital, Tachikawa, Japan.
Footnotes
Accepted for publication Feb 3, 1978.
Read before the 41st meeting of the East Japan Dermatological Society, Tokyo, Sept 24, 1977.
Reprint requests to Department of Dermatology, Keio University School of Medicine, Tokyo 160, Japan (Dr Hatano).
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