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Nicole Hunziker, MD; R. K. Winkelmann, MD, PhD

Arch Dermatol. 1978;114(9):1309-1313.

Abstract
• In the guinea pig, the epidermal Langerhans cells studied by adenosine triphosphatase and electron microscopic techniques in dinitrochlorobenzene-induced contact dermatitis showed early cellular vacuolar and granular changes and intraepidermal contact with mononuclear cells. At later periods of up to 48 hours, the Langerhans cells migrated to the surface of a thickened epidermis and were lost in the parakeratotic horny layer that was shed. Thus, the Langerhans cell probably has a macrophage-type role in the epidermal reaction of contact dermatitis, and as the spongiosis and the inflammatory reaction develop, these cells are shed with the degenerating keratinocytes.

(Arch Dermatol 114:1309-1313, 1978)

Author Affiliations
From the Mayo Clinic and Mayo Foundation, Rochester, Minn.

Footnotes
Accepted for publication May 19, 1978.

Reprint requests to Section of Publications, Mayo Clinic, 200 First St SW, Rochester, MN 55901 (Dr Hunziker).

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