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Randomized Double-Blind Evaluation

Clifton R. White, MD; Jon M. Hanifin, MD

Arch Dermatol. 1978;114(9):1314-1315.

Abstract
• A randomized double-blind study of levamisole hydrochloride therapy in atopic dermatitis is reported. No improvement was noted in any of several assessments, which included patients' subjective impressions; physicians' clinical impressions; comparison of clinical extent and severity scores; and incidence of cutaneous infections or lessening of serum IgE levels. A trend toward improvement was seen in a majority of cases, whether treatment was with a placebo or an active drug. This study emphasizes the need for double-blind techniques for therapeutic trial in the management of patients with atopic dermatitis.

(Arch Dermatol 114:1314-1315, 1978)

Author Affiliations
From the University of Oregon Health Sciences Center, Portland, Ore.

Footnotes
Accepted for publication April 6, 1978.

Reprint requests to the University of Oregon Health Sciences Center, 3181 SW Sam Jackson Park Rd, Portland, OR 97201 (Dr Hanifin).

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