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A Clinical and Histological Study

Nicholas J. Lowe, MD, MRCP; Derek J. Cripps, MD; P. A. Dufton, MB, MRCP; C. F. H. Vickers, MD, FRCP

Arch Dermatol. 1979;115(1):50-53.

Abstract
Nine patients with stages 2 or 3 mycosis fungoides (MF) and one with Sézary's syndrome were treated with oral methoxsalen and long-wave ultraviolet light. Previous therapy had either failed or achieved only partial control. Satisfactory clinical control was achieved in all but one case. Histological improvement was seen in all cases, but complete clearance of lymphoid infiltrate was noted mainly in epidermal and papillary dermal infiltrates. Lower dermal infiltrate remained largely unchanged.

The case of Sézary's syndrome was inadequately controlled with systemic prednisone and cyclophosphamide, but addition of photochemotherapy improved the erythema and pruritus. This shows that photochemotherapy may have a place in MF treatment both alone and perhaps in conjunction with other treatments. An early relapse occurred on stopping photochemotherapy in four cases, but one patient has had three months' full remission.

(Arch Dermatol 115:50-53, 1979)

Author Affiliations
From the University of Wisconsin, Madison (Drs Lowe and Cripps) and the University of Liverpool, England (Drs Dufton and Vickers). Dr Lowe is now with the Division of Dermatology, UCLA School of Medicine, Los Angeles.

Footnotes
Accepted for publication Aug 11, 1978.

Reprints not available.

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