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Its Dermatological Manifestations and Some Additional Biochemical Studies

Jirô Arata, MD; Shigeo Umemura, MD; Yasuo Yamamoto, MD; Masaharu Hagiyama, MD; Nozomi Nohara, MD

Arch Dermatol. 1979;115(1):62-67.

Abstract
Prolidase deficiency occurred in a 13-year-old girl. Determinations were made of prolidase and prolinase activities in cultured fibroblasts, and thin layer chromatographic studies of skin prolidase were performed. The patient had chronic, recurrent ulcers on the legs and feet, diffuse telangiectasia, shallow scarlike atrophic lesions on the face and arms, soft and thin abdominal skin, and premature gray hairs. Prolidase in the patient's skin fibroblasts was absent. Greatly reduced prolidase activity was demonstrated in the patient's skin. A review of hitherto reported cases of this disease showed such skin manifestations as (1) skin ulceration or skin fragility with scar formation, (2) purpuric lesions, (3) telangiectasia and/or photosensitivity, and (4) thickening of the skin with lymphedema.

(Arch Dermatol 115:62-67, 1979)

Author Affiliations
From the Department of Dermatology, Okayama (Japan) University Medical School.

Footnotes
Accepted for publication Aug 9, 1978.

Reprint requests to Department of Dermatology, Okayama University Medical School, Shikatacho 2-5-1, Okayama 700, Japan (Dr Arata).

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