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Occurrence in a Patient With Psoriasis After Topical, Systemic, and PUVA Therapy

Dominic W. Tam, MD; Eugene J. Van Scott, MD; Frederick Urbach, MD

Arch Dermatol. 1979;115(2):203-204.

Abstract
Multiple lesions of Bowen's disease and squamous cell carcinoma on the penis and pubic areas developed in a 32-year-old patient with psoriasis who was undergoing treatment with psoralen and long-wave ultraviolet radiation (PUVA). A cumulative dose of more than 3,700 joules/sq cm of UVA had been administered over a three-year period. This case may be an early warning of possible carcinogenicity of PUVA therapy, alone or as part of sequential therapy with other agents.

(Arch Dermatol 115:203-204, 1979)

Author Affiliations
From the Department of Dermatology, Skin and Cancer Hospital, Temple University School of Medicine, Philadelphia.

Footnotes
Accepted for publication Sept 6, 1978.

Reprint requests to Skin and Cancer Hospital, 3322 N Broad St, Philadelphia, PA 19140 (Dr Van Scott).

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