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MAJ Ronald Grimwood, MC; James M. Swinehart, MD; COL John L. Aeling, MC

Arch Dermatol. 1979;115(2):205-207.

Abstract
Angiolymphoid hyperplasia with eosinophilia (AHE) is a distinct clinical and pathologic entity that demonstrates proliferation of endothelial cells associated with varying degrees of lymphocytic, histiocytic, and eosinophilic infiltration. Lymphoid hyperplasia with germinal centers often is present in older lesions and the patients may have an associated blood eosinophilia. Multiple deep nodules developed in a young man on the palmar aspect of the left hand, and subsequently the forehead, histologically diagnostic of AHE. Direct immunofluorescence of the tumor removed from the forehead demonstrated granular deposits of IgA, IgM, and C3 associated with small vessels. Cryoglobulins (IgA, IgM, and IgG) were found in the patient's serum. This new information lends support to the hypothesis that AHE is an inflammatory reactive lesion, possibly secondary to an immunologic injury, rather than a true vascular neoplasm with an associated inflammatory reaction.

(Arch Dermatol 115:205-207, 1979)

Author Affiliations
USA; USA

From the Dermatology Services, Fitzsimons Army Medical Center (Drs Grimwood and Aeling) and University of Colorado Medical Center (Dr Swinehart), Denver.

Footnotes
Accepted for publication Sept 27, 1978.

The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.

Reprint requests to Dermatology Service, Fitzsimons Army Medical Center, Denver, CO 80240 (Dr Grimwood).

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