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In Vivo Bound Pemphigus Antibodies in a Stillborn InfantPassive Intrauterine Transfer of Pemphigus Vulgaris?
Hylke Terpstra, MD;
Marcel C. J. M. de Jong, PhD;
A. H. Klokke, MD
Arch Dermatol. 1979;115(3):316-319.
Abstract
Pemphigus vulgaris developed in a 23-year-old woman during the first trimester of pregnancy. In the 33d week she had a stillbirth of a female child who showed extensive skin lesions clinically suggestive of pemphigus. The application of direct immunofluorescence staining to skin tissue sections showed deposition of IgG in the intercellular spaces of the epidermis of both mother and child.
Our findings raise the possibility of transplacentar passage of pemphigus antibody, which may have been responsible for the fetal skin lesions.
(Arch Dermatol 115:316-319, 1979)
Author Affiliations
From the Department of Dermatology, State University, Groningen, The Netherlands.
Footnotes
Accepted for publication Oct 6, 1978.
Reprint requests to Department of Dermatology, State University, Oostersingel 59, 9713 EZ Groningen, The Netherlands (Dr de Jong).
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