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Cutaneous T-Cell Lymphoma in Association With a Monoclonal Gammopathy
Miles V. Joyner, MRCPath;
J-Patrice Cassuto, MD;
Pierre Dujardin, MD;
Marcel Barety, MD;
Hughette Duplay, MD;
Paul Audoly, MD
Arch Dermatol. 1979;115(3):326-328.
Abstract
Monoclonal gammopathies and other abnormalities of immunoglobulin production may characterize or frequently be associated with B-cell lymphoproliferative disorders. We describe a patient with a T-cell cutaneous lymphoma, expressed clinically as Sézary's syndrome, in association with an immunoglobulin A type kappa M-component monoclonal gammopathy. No evidence for the coincident presence of a malignant plasma dyscrasia was found. This clinical association may lend clinical support to the concept that Sézary's syndrome is a T-helper-cell malignant proliferation. A colonic carcinoma was also present, possibly representing a second manifestation of a functionally abnormal cellular immune system.
(Arch Dermatol 115:326-328, 1979)
Author Affiliations
From the Department of Haematology, Clinique Medicale du Professeur Audoly, Hopital de Cimiez, Nice, France. Dr Joyner is presently with the Department of Haemotology, King's College Hospital, London.
Footnotes
Accepted for publication Nov 7, 1978.
Reprint requests to Department of Haematology, King's College Hospital Medical School, Denmark Hill, London, SE5 8RX, England (Dr Joyner).
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