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Sylvia M. Wallace, PhD; Helen M. Falkenberg, MSc; John O. Runikis, PhD; William D. Stewart, MD

Arch Dermatol. 1979;115(4):440-441.

Abstract
Ointment containing 2.5% hydrocortisone was applied topically under occlusion to 84 subjects. Fifty-three percent of the population showed skin blanching in response to topical application of the steroid. To correlate vasoconstrictor response with drug level, hydrocortisone concentrations were determined fluorometrically in skin samples from 16 subjects in whom skin blanching was also assessed. The epidermal concentration of hydrocortisone was significantly greater in those subjects who exhibited blanching. Data suggest that a minimum epidermal reservoir of 200 µg of hydrocortisone per gram of lyophilized tissue is necessary to elicit a definite vasoconstrictor response.

(Arch Dermatol 115:440-441, 1979)

Author Affiliations
From the Faculty of Pharmaceutical Sciences (Dr Wallace, Ms Falkenberg, and Dr Runikis) and Division of Dermatology, Department of Medicine, Faculty of Medicine (Dr Stewart), University of British Columbia, Vancouver, Canada.

Footnotes
Accepted for publication Sept 27, 1978.

Reprint requests to College of Pharmacy, University of Saskatchewan, Saskatoon, Canada, S7N OWO (Dr Wallace).

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