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Identification of a Neutrophil Chemotactic Inhibitor in a Patient With Recurrent Pyoderma
Lawrence D. Robinson, Jr, MD;
Sandra K. Wooten, MS;
A. Paul Kelly, MD
Arch Dermatol. 1979;115(4):453-457.
Abstract
Host defense mechanisms were studied in a patient with recurrent pyoderma of the scalp. Evaluation of the patient's inflammatory response demonstrated normal yeast phagocytosis, normal capillary tube migration, normal results from a nitroblue tetrazolium dye test, and significantly decreased neutrophil chemotactic response (NC). The impaired NC was associated with a heat labile plasma inhibitor. Chromatography of the patient's and of normal human plasma demonstrated three distinct protein peaks. Chemotactic inhibitory activity was found in the third peak of the patient's plasma but not in the control plasma. Normal in vitro NC was restored when greater than 40% normal human plasma was added to the column fractions that contained the inhibitor. Based on these findings, a subsequent exacerbation of the patient's pyoderma was treated with fresh frozen plasma, and dramatic clinical improvement occurred within 72 hours.
(Arch Dermatol 115:453-457, 1979)
Author Affiliations
From the Departments of Pediatrics (Dr Robinson) and Medicine (Dr Kelly), Division of Dermatology (Dr Kelly), Martin Luther King Jr General Hospital, and Charles R. Drew Postgraduate Medical School, Los Angeles.
Footnotes
Accepted for publication Sept 27, 1978.
Read before the American Congress of Allergy and Immunology, New York, March 17, 1977.
Reprint requests to Charles R. Drew Postgraduate Medical School, Office of Research Programs, 1621 E 120th St, Los Angeles, CA 90059 (Dr Robinson).
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