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Hereditary Acrolabial TelangiectasiaA Report of Familial Blue Lips, Nails, and Nipples
John L. Millns, MD;
Charles H. Dicken, MD
Arch Dermatol. 1979;115(4):474-478.
Abstract
We describe a mother and two daughters who had the following clinical manifestations: bluish discoloration of the vermilion ridge of the lips, nipple areolae, and nail beds; discrete telangiectasia of the chest, elbows, and dorsa of the hands; varicosities of the lower part of the legs; and (in the two daughters) migraine headaches. Routine histologic examination of tissue from the lips and elbows disclosed extensive, dilated, horizontal subpapillary telangiectases. Enzyme histochemical stains demonstrated activity of adenosine triphosphatase and leucine aminopeptidase around these dilated vessels. Alkaline phosphatase activity was strikingly absent from the dilated subpapillary vessels. By electron microscopy, these vessels were demonstrated to be postcapillary venules. We propose an autosomal dominant mode of inheritance.
(Arch Dermatol 115:474-478, 1979)
Author Affiliations
From the Mayo Clinic and Mayo Foundation, Rochester, Minn.
Footnotes
Accepted for publication Oct 31, 1978.
Read before the 127th annual meeting of the American Medical Association, St Louis, June 18, 1978.
Reprint requests to Section of Publications, Mayo Clinic, 200 First St SW, Rochester, MN 55901 (Dr Millns).
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