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Michael L. Reed, MD; John Stanley, MD; Fernando Stengel, MD; Jerome L. Shupack, MD; David M. Benjamin, PhD

Arch Dermatol. 1979;115(5):605-608.

Abstract
Identical twins with mal de Meleda, a rare genodermatosis, displayed the characteristic "glove and sock" hyperkeratosis, hyperhidrosis, and malodor. Their parents, who are first cousins, are unaffected and originated from Calabria, Italy, which is not far from Meleda (Mljet). The disorder is probably transmitted as an autosomal recessive trait. Previous therapy with grenz rays, topical preparations of adrenocorticosteroids, lactic acid, retinoic acid, and bland emollients had been unsuccessful. One of the twins was treated with 13-cis retinoic acid taken by mouth for 16 weeks with dramatic improvement. The major adverse effect was cheilitis, which did not force discontinuation of the treatment.

(Arch Dermatol 115:605-608, 1979)

Author Affiliations
From the Department of Dermatology, Division of Dermatopharmacology, New York University School of Medicine, New York (Drs Reed, Stanley, Stengel, and Shupack), and Department of Medical Research, Hoffmann-LaRoche, Inc, Nutley, NJ (Dr Benjamin).

Footnotes
Accepted for publication Dec 5, 1978.

Reprint requests to Section of Dermatopharmacology, Skin and Cancer Unit, New York University Medical Center, 566 First Ave, New York, NY 10016 (Dr Reed).

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